Structural highlights
Function
CTKA_HELPJ Virulence factor acting as a pro-inflammatory protein that induces the secretion of the pro-inflammatory cytokines TNF-alpha (tumor necrosis factor-alpha) and IL-8 (interleukin-8) from human macrophages, as well as enhanced translocation of the transcription factor NF-kappa-B complex in macrophages. Is a kinase capable of autophosphorylating itself at a threonine residue near the N-terminus. Also leads to enhanced phosphorylation of the NF-kappa-B p65 subunit (RELA) at 'Ser-276' in human epithelial cancer cells; its kinase activity is required for this enhanced phosphorylation that up-regulates NF-kappa-B activity, but it does not directly phosphorylate this protein. Thus, the kinase activity of CtkA may play an important role in the induction of host inflammatory responses during H.pylori infection.[1] [2]
References
- ↑ Rizwan M, Alvi A, Ahmed N. Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages. J Bacteriol. 2008 Feb;190(3):1146-51. PMID:17993522 doi:10.1128/JB.01309-07
- ↑ Kim do J, Park KS, Kim JH, Yang SH, Yoon JY, Han BG, Kim HS, Lee SJ, Jang JY, Kim KH, Kim MJ, Song JS, Kim HJ, Park CM, Lee SK, Lee BI, Suh SW. Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21418-23. Epub 2010 Nov 22. PMID:21098302 doi:10.1073/pnas.1010153107
