3bsf

Structural highlights

Function

MTN2_ARATH Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis.^{[1] [2] [3] [4]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Burstenbinder K, Rzewuski G, Wirtz M, Hell R, Sauter M. The role of methionine recycling for ethylene synthesis in Arabidopsis. Plant J. 2007 Jan;49(2):238-49. Epub 2006 Nov 27. PMID:17144895 doi:http://dx.doi.org/10.1111/j.1365-313X.2006.02942.x
2. ↑ Siu KK, Lee JE, Sufrin JR, Moffatt BA, McMillan M, Cornell KA, Isom C, Howell PL. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases. J Mol Biol. 2008 Apr 18;378(1):112-28. Epub 2008 Feb 8. PMID:18342331 doi:10.1016/j.jmb.2008.01.088
3. ↑ Burstenbinder K, Waduwara I, Schoor S, Moffatt BA, Wirtz M, Minocha SC, Oppermann Y, Bouchereau A, Hell R, Sauter M. Inhibition of 5'-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis. Plant J. 2010 Jun 1;62(6):977-88. doi: 10.1111/j.1365-313X.2010.04211.x. Epub, 2010 Mar 19. PMID:20345605 doi:http://dx.doi.org/10.1111/j.1365-313X.2010.04211.x
4. ↑ Siu KK, Asmus K, Zhang AN, Horvatin C, Li S, Liu T, Moffatt B, Woods VL Jr, Howell PL. Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. J Struct Biol. 2010 Jun 8. PMID:20554051 doi:10.1016/j.jsb.2010.06.006