3e59

Structural highlights

Function

PVCA_PSEAE Involved in the biosynthesis of paerucumarin, a cyclized isocyano derivative of tyrosine (PubMed:18689486, PubMed:18824174). Responsible for the synthesis of the isonitrile group on tyrosine using the C2 of ribulose 5-phosphate as the source of the carbon atom (Probable).^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Clarke-Pearson MF, Brady SF. Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa. J Bacteriol. 2008 Oct;190(20):6927-30. PMID:18689486 doi:10.1128/JB.00801-08
2. ↑ Drake EJ, Gulick AM. Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin. J Mol Biol. 2008 Dec 5;384(1):193-205. Epub 2008 Sep 19. PMID:18824174 doi:10.1016/j.jmb.2008.09.027
3. ↑ Drake EJ, Gulick AM. Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin. J Mol Biol. 2008 Dec 5;384(1):193-205. Epub 2008 Sep 19. PMID:18824174 doi:10.1016/j.jmb.2008.09.027