Structural highlights
Function
CHEY1_HELPY Chemotactic response regulator protein that modulates the rotation direction of bacterial flagellar motors. Plays an important role in the colonization and infection of Helicobacter pylori (PubMed:10722597). Upon phosphorylation by CheA, interacts with the flagellar motor protein FliM to cause clockwise flagellar rotation and bacterial reversals, as opposed to straight swimming when CheY1 is not phosphorylated (PubMed:20207758).[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
References
- ↑ Foynes S, Dorrell N, Ward SJ, Stabler RA, McColm AA, Rycroft AN, Wren BW. Helicobacter pylori possesses two CheY response regulators and a histidine kinase sensor, CheA, which are essential for chemotaxis and colonization of the gastric mucosa. Infect Immun. 2000 Apr;68(4):2016-23. PMID:10722597 doi:10.1128/IAI.68.4.2016-2023.2000
- ↑ Lam KH, Ling TK, Au SW. Crystal structure of activated CheY1 from Helicobacter pylori. J Bacteriol. 2010 May;192(9):2324-34. Epub 2010 Mar 5. PMID:20207758 doi:10.1128/JB.00603-09
