3kg0

Structural highlights

Function

SNOAB_STRNO Involved in the biosynthesis of the anthracycline (aromatic polyketide) antibiotic nogalamycin (PubMed:8760909, PubMed:8668120). Catalyzes the oxygenation of 12-deoxy-nogalonic acid at position 12 to yield nogalonic acid (PubMed:19255477, PubMed:20052967).^{[1] [2] [3] [4]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mäntsälä P. A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway. Mol Gen Genet. 1996 May 23;251(2):113-20. PMID:8668120 doi:10.1007/BF02172908
2. ↑ Ylihonko K, Hakala J, Kunnari T, Mäntsälä P. Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes. Microbiology (Reading). 1996 Aug;142 ( Pt 8):1965-72. PMID:8760909 doi:10.1099/13500872-142-8-1965
3. ↑ Koskiniemi H, Grocholski T, Schneider G, Niemi J. Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt, 3):256-9. Epub 2009 Feb 14. PMID:19255477 doi:10.1107/S1744309109001389
4. ↑ Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G. Crystal Structure of the Cofactor-Independent Monooxygenase SnoaB from Streptomyces nogalater: Implications for the Reaction Mechanism. Biochemistry. 2010 Jan 12. PMID:20052967 doi:10.1021/bi901985b