Structural highlights
Function
MTIP_PSEAE Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Involved in quorum sensing.[HAMAP-Rule:MF_01963][1]
References
- ↑ Guan R, Ho MC, Almo SC, Schramm VL. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry. 2011 Feb 22;50(7):1247-54. Epub 2011 Jan 25. PMID:21197954 doi:10.1021/bi101642d
