3qwx

Structural highlights

Function

CED2_CAEEL Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).^{[1] [2] [3] [4] [5] [6]}

See Also

• Cell death protein 3D structures

References

1. ↑ Reddien PW, Horvitz HR. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol. 2000 Mar;2(3):131-6. PMID:10707082 doi:http://dx.doi.org/10.1038/35004000
2. ↑ Reddien PW, Cameron S, Horvitz HR. Phagocytosis promotes programmed cell death in C. elegans. Nature. 2001 Jul 12;412(6843):198-202. PMID:11449278 doi:http://dx.doi.org/10.1038/35084096
3. ↑ Kinchen JM, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, Schnabel R, Hengartner MO. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005 Mar 3;434(7029):93-9. PMID:15744306 doi:http://dx.doi.org/nature03263
4. ↑ Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991 Sep;129(1):79-94. PMID:1936965
5. ↑ Hurwitz ME, Vanderzalm PJ, Bloom L, Goldman J, Garriga G, Horvitz HR. Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol. 2009 Apr 28;7(4):e99. doi: 10.1371/journal.pbio.1000099. PMID:19402756 doi:http://dx.doi.org/10.1371/journal.pbio.1000099
6. ↑ Hedgecock EM, Sulston JE, Thomson JN. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science. 1983 Jun 17;220(4603):1277-9. PMID:6857247