Structural highlights
Function
MRS2_YEAST High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.[1] [2] [3] [4]
References
- ↑ Gregan J, Kolisek M, Schweyen RJ. Mitochondrial Mg(2+) homeostasis is critical for group II intron splicing in vivo. Genes Dev. 2001 Sep 1;15(17):2229-37. PMID:11544180 doi:10.1101/gad.201301
- ↑ Kolisek M, Zsurka G, Samaj J, Weghuber J, Schweyen RJ, Schweigel M. Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J. 2003 Mar 17;22(6):1235-44. PMID:12628916 doi:10.1093/emboj/cdg122
- ↑ Schindl R, Weghuber J, Romanin C, Schweyen RJ. Mrs2p forms a high conductance Mg2+ selective channel in mitochondria. Biophys J. 2007 Dec 1;93(11):3872-83. Epub 2007 Sep 7. PMID:17827224 doi:10.1529/biophysj.107.112318
- ↑ Sponder G, Svidova S, Schindl R, Wieser S, Schweyen RJ, Romanin C, Froschauer EM, Weghuber J. Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel. FEBS J. 2010 Sep;277(17):3514-25. doi: 10.1111/j.1742-4658.2010.07761.x. Epub, 2010 Jul 23. PMID:20653776 doi:10.1111/j.1742-4658.2010.07761.x
