3t7v

Structural highlights

Function

PYLB_METBF Catalyzes the isomerization of L-lysine to (2R,3R)-3-methylornithine via a radical-based mechanism, a step in the biosynthesis pathway of pyrrolysine.^{[1] [2]}

References

1. ↑ Gaston MA, Zhang L, Green-Church KB, Krzycki JA. The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine. Nature. 2011 Mar 31;471(7340):647-50. doi: 10.1038/nature09918. PMID:21455182 doi:http://dx.doi.org/10.1038/nature09918
2. ↑ Quitterer F, List A, Eisenreich W, Bacher A, Groll M. Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis. Angew Chem Int Ed Engl. 2011 Nov 16. doi: 10.1002/anie.201106765. PMID:22095926 doi:10.1002/anie.201106765