3tuf

Structural highlights

Function

SP2Q_BACSU Involved in forespore engulfment and required for anchoring membrane proteins on the forespore side of the septal membrane. Forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.^{[1] [2] [3] [4] [5] [6] [7] [8] [9] [10]}

References

1. ↑ Londono-Vallejo JA, Frehel C, Stragier P. SpoIIQ, a forespore-expressed gene required for engulfment in Bacillus subtilis. Mol Microbiol. 1997 Apr;24(1):29-39. PMID:9140963
2. ↑ Sun YL, Sharp MD, Pogliano K. A dispensable role for forespore-specific gene expression in engulfment of the forespore during sporulation of Bacillus subtilis. J Bacteriol. 2000 May;182(10):2919-27. PMID:10781563
3. ↑ Dworkin J, Losick R. Developmental commitment in a bacterium. Cell. 2005 May 6;121(3):401-9. PMID:15882622 doi:http://dx.doi.org/10.1016/j.cell.2005.02.032
4. ↑ Doan T, Marquis KA, Rudner DZ. Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum. Mol Microbiol. 2005 Mar;55(6):1767-81. PMID:15752199 doi:http://dx.doi.org/10.1111/j.1365-2958.2005.04501.x
5. ↑ Jiang X, Rubio A, Chiba S, Pogliano K. Engulfment-regulated proteolysis of SpoIIQ: evidence that dual checkpoints control sigma activity. Mol Microbiol. 2005 Oct;58(1):102-15. PMID:16164552 doi:http://dx.doi.org/MMI4811
6. ↑ Broder DH, Pogliano K. Forespore engulfment mediated by a ratchet-like mechanism. Cell. 2006 Sep 8;126(5):917-28. PMID:16959571 doi:http://dx.doi.org/10.1016/j.cell.2006.06.053
7. ↑ Aung S, Shum J, Abanes-De Mello A, Broder DH, Fredlund-Gutierrez J, Chiba S, Pogliano K. Dual localization pathways for the engulfment proteins during Bacillus subtilis sporulation. Mol Microbiol. 2007 Sep;65(6):1534-46. PMID:17824930 doi:http://dx.doi.org/MMI5887
8. ↑ Campo N, Marquis KA, Rudner DZ. SpoIIQ anchors membrane proteins on both sides of the sporulation septum in Bacillus subtilis. J Biol Chem. 2008 Feb 22;283(8):4975-82. Epub 2007 Dec 11. PMID:18077456 doi:http://dx.doi.org/10.1074/jbc.M708024200
9. ↑ Camp AH, Losick R. A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels. Mol Microbiol. 2008 Jul;69(2):402-17. doi: 10.1111/j.1365-2958.2008.06289.x. PMID:18485064 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06289.x
10. ↑ Meisner J, Wang X, Serrano M, Henriques AO, Moran CP Jr. A channel connecting the mother cell and forespore during bacterial endospore formation. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15100-5. doi:, 10.1073/pnas.0806301105. Epub 2008 Sep 23. PMID:18812514 doi:http://dx.doi.org/10.1073/pnas.0806301105