3umv

Structural highlights

Function

PHR_ORYSJ Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutylpyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Required for plant survival in the presence of UV-B light. Not involved in the repair of (6-4) photoproducts.^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Hirouchi T, Nakajima S, Najrana T, Tanaka M, Matsunaga T, Hidema J, Teranishi M, Fujino T, Kumagai T, Yamamoto K. A gene for a Class II DNA photolyase from Oryza sativa: cloning of the cDNA by dilution-amplification. Mol Genet Genomics. 2003 Jul;269(4):508-16. Epub 2003 May 22. PMID:12764611 doi:http://dx.doi.org/10.1007/s00438-003-0856-9
2. ↑ Ueda T, Sato T, Hidema J, Hirouchi T, Yamamoto K, Kumagai T, Yano M. qUVR-10, a major quantitative trait locus for ultraviolet-B resistance in rice, encodes cyclobutane pyrimidine dimer photolyase. Genetics. 2005 Dec;171(4):1941-50. Epub 2005 Jun 18. PMID:15965242 doi:http://dx.doi.org/10.1534/genetics.105.044735
3. ↑ Yamamoto A, Hirouchi T, Mori T, Teranishi M, Hidema J, Morioka H, Kumagai T, Yamamoto K. Biochemical and biological properties of DNA photolyases derived from utraviolet-sensitive rice cultivars. Genes Genet Syst. 2007 Aug;82(4):311-9. PMID:17895582
4. ↑ Hidema J, Taguchi T, Ono T, Teranishi M, Yamamoto K, Kumagai T. Increase in CPD photolyase activity functions effectively to prevent growth inhibition caused by UVB radiation. Plant J. 2007 Apr;50(1):70-9. PMID:17397507 doi:http://dx.doi.org/10.1111/j.1365-313X.2007.03041.x
5. ↑ Teranishi M, Nakamura K, Morioka H, Yamamoto K, Hidema J. The native cyclobutane pyrimidine dimer photolyase of rice is phosphorylated. Plant Physiol. 2008 Apr;146(4):1941-51. doi: 10.1104/pp.107.110189. Epub 2008 Jan, 30. PMID:18235036 doi:http://dx.doi.org/10.1104/pp.107.110189
6. ↑ Okafuji A, Biskup T, Hitomi K, Getzoff ED, Kaiser G, Batschauer A, Bacher A, Hidema J, Teranishi M, Yamamoto K, Schleicher E, Weber S. Light-induced activation of class II cyclobutane pyrimidine dimer photolyases. DNA Repair (Amst). 2010 May 4;9(5):495-505. doi: 10.1016/j.dnarep.2010.01.014., Epub 2010 Mar 15. PMID:20227927 doi:http://dx.doi.org/10.1016/j.dnarep.2010.01.014