Structural highlights
Function
KHDC3_MOUSE Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.[1] [2]
References
- ↑ Zheng P, Dean J. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7473-8. doi:, 10.1073/pnas.0900519106. Epub 2009 Apr 17. PMID:19376971 doi:http://dx.doi.org/10.1073/pnas.0900519106
- ↑ Wang J, Xu M, Zhu K, Li L, Liu X. The N-terminus of FILIA Forms an Atypical KH Domain with a Unique Extension Involved in Interaction with RNA. PLoS One. 2012;7(1):e30209. Epub 2012 Jan 19. PMID:22276159 doi:10.1371/journal.pone.0030209
