Structural highlights
4bwm is a 3 chain structure with sequence from Thermus aquaticus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.749Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
DPO1_THEAQ
Publication Abstract from PubMed
Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally characterized. The DNA polymerase variant has significant reverse transcriptase activity that allows its application in PCR-based molecular diagnostics.
Structure and Function of an RNA-Reading Thermostable DNA Polymerase.,Blatter N, Bergen K, Nolte O, Welte W, Diederichs K, Mayer J, Wieland M, Marx A Angew Chem Int Ed Engl. 2013 Sep 17. doi: 10.1002/anie.201306655. PMID:24106012[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Blatter N, Bergen K, Nolte O, Welte W, Diederichs K, Mayer J, Wieland M, Marx A. Structure and Function of an RNA-Reading Thermostable DNA Polymerase. Angew Chem Int Ed Engl. 2013 Sep 17. doi: 10.1002/anie.201306655. PMID:24106012 doi:http://dx.doi.org/10.1002/anie.201306655
