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4g8z

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pcDHFR K37S/F69N double mutant TMP NADPH ternary complex

Structural highlights

4g8z is a 1 chain structure with sequence from Pneumocystis jirovecii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:NDP, TOP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_PNECA Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

See Also

Contents


PDB ID 4g8z

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OCA

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