4hrv

Publication Abstract from PubMed

GNA1162, a predicted lipoprotein from Neisseria meningitidis, is a potential candidate for a universal vaccine against meningococcal disease caused by N. meningitidis serogroup B. Here, the crystal structure of GNA1162 at 1.89 A resolution determined by single-wavelength anomalous dispersion (SAD) is reported. The structure of GNA1162 appears to be a dimer in the crystallographic asymmetric unit as well as in solution. The overall structure of the dimer indicates that each monomer inserts its C-terminal alpha5 helix into the hydrophobic groove of the other molecule. Moreover, the beta4 strands of each monomer lie antiparallel to each other and interact through multiple main-chain hydrogen bonds. Through structural comparisons and operon predictions, it is hypothesized that GNA1162 is part of a transport system and assists in transport and reassembly. The crystal structure of GNA1162 sheds light on its possible function and provides potentially valuable information for the design of a vaccine against meningococcal disease.

Structure of Neisseria meningitidis lipoprotein GNA1162.,Cai X, Lu J, Wu Z, Yang C, Xu H, Lin Z, Shen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):362-8. doi:, 10.1107/S1744309113004417. Epub 2013 Mar 28. PMID:23545639^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.