4ip8

Structural highlights

Disease

SAA1_HUMAN Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.

Function

SAA1_HUMAN Major acute phase reactant. Apolipoprotein of the HDL complex.