Structural highlights
4jo0 is a 1 chain structure with sequence from Streptomyces venezuelae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.17Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
CMLA_STRVP Involved in chloramphenicol biosynthesis (PubMed:20713732). Catalyzes the beta-hydroxylation of 4-amino-L-phenylalanine (L-PAPA) covalently bound to CmlP to form L-p-aminophenylserine (PubMed:20713732).[1]
References
- ↑ Makris TM, Chakrabarti M, Munck E, Lipscomb JD. A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15391-6. doi: , 10.1073/pnas.1007953107. Epub 2010 Aug 16. PMID:20713732 doi:http://dx.doi.org/10.1073/pnas.1007953107
