4k7e
From Proteopedia
Crystal structure of Junin virus nucleoprotein
Structural highlights
FunctionQ6IVU2_JUNIN Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses (By similarity).[PIRNR:PIRNR004029] Publication Abstract from PubMedJunin virus (JUNV) is identified as the etiological agent of Argentine hemorrhagic fever (AHF), which leads to a serious public health problem with approximately five million people at risk. It is treated as a potential bioterrorism agent for its rapid transmission by aerosols. JUNV is a negative-sense single-stranded RNA (-ssRNA) virus that belongs to the genus Arenavirus within the family Arenaviridae and its genomic RNA contains two segments encoding four proteins. Among these proteins, the nucleoprotein (NP) has essential roles in viral RNA synthesis and immune suppression, but the molecular mechanisms are only partially understood. Here, we represent a 2.2 A crystal structure of the C-terminal domain of JUNV NP. This structure shows high similarity with the Lassa fever virus (LASV) NP C-terminal domain. However, both the structure and function show differences compare to the LASV NP. This study extends our structural insight into the -ssRNA virus nucleoproteins. Crystal structure of Junin virus nucleoprotein.,Zhang Y, Li L, Liu X, Dong S, Wang W, Huo T, Guo Y, Rao Z, Yang C J Gen Virol. 2013 Jul 24. PMID:23884367[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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Categories: Argentinian mammarenavirus | Large Structures | Dong SS | Huo T | Li L | Liu X | Rao ZH | Wang WM | Yang C | Zhang YJ
