4ke2

Structural highlights

Function

ANPM_PSEAM Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point by about 1.1 degrees at a concentration of 0.1 mg/ml, and by about 1.5 degrees at a concentration of 0.2 mg/ml. Binds to nascent ice crystals and prevents further growth.^{[1] [2] [3] [4]}

See Also

• Antifreeze protein 3D structures

References

1. ↑ Marshall CB, Fletcher GL, Davies PL. Hyperactive antifreeze protein in a fish. Nature. 2004 May 13;429(6988):153. doi: 10.1038/429153a. PMID:15141201 doi:http://dx.doi.org/10.1038/429153a
2. ↑ Marshall CB, Chakrabartty A, Davies PL. Hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of alpha-helices. J Biol Chem. 2005 May 6;280(18):17920-9. Epub 2005 Feb 16. PMID:15716269 doi:http://dx.doi.org/10.1074/jbc.M500622200
3. ↑ Graham LA, Marshall CB, Lin FH, Campbell RL, Davies PL. Hyperactive antifreeze protein from fish contains multiple ice-binding sites. Biochemistry. 2008 Feb 19;47(7):2051-63. doi: 10.1021/bi7020316. Epub 2008 Jan, 29. PMID:18225917 doi:http://dx.doi.org/10.1021/bi7020316
4. ↑ Sun T, Lin FH, Campbell RL, Allingham JS, Davies PL. An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters. Science. 2014 Feb 14;343(6172):795-8. doi: 10.1126/science.1247407. PMID:24531972 doi:http://dx.doi.org/10.1126/science.1247407