4lin

Structural highlights

Function

NEEDL_BPP22 Cell-perforating component and plug protein of the phage tail machine. Host cell membrane perforation allows viral DNA ejection. Together with gp4 and gp10, gp26 is required for stabilization of the condensed DNA within the capsid by plugging the hole through which the DNA enters.^{[1] [2]}

References

1. ↑ Olia AS, Casjens S, Cingolani G. Structure of phage P22 cell envelope-penetrating needle. Nat Struct Mol Biol. 2007 Dec 2. PMID:18059287 doi:10.1038/nsmb1317
2. ↑ Andres D, Hanke C, Baxa U, Seul A, Barbirz S, Seckler R. Tailspike interactions with lipopolysaccharide effect DNA ejection from phage P22 particles in vitro. J Biol Chem. 2010 Nov 19;285(47):36768-75. doi: 10.1074/jbc.M110.169003. Epub, 2010 Sep 3. PMID:20817910 doi:http://dx.doi.org/10.1074/jbc.M110.169003