4mhr

Structural highlights

Function

ECTD_SPHAL Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.^{[1] [2]}

See Also

• Hydroxylases 3D structures

References

1. ↑ Widderich N, Hoppner A, Pittelkow M, Heider J, Smits SH, Bremer E. Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms. PLoS One. 2014 Apr 8;9(4):e93809. doi: 10.1371/journal.pone.0093809. eCollection , 2014. PMID:24714029 doi:http://dx.doi.org/10.1371/journal.pone.0093809
2. ↑ Hoeppner A, Widderich N, Lenders M, Bremer E, Smits SH. Crystal Structure of the Ectoine Hydroxylase: a Snapshot of the Active Site. J Biol Chem. 2014 Aug 29. pii: jbc.M114.576769. PMID:25172507 doi:http://dx.doi.org/10.1074/jbc.M114.576769