4mr0

Structural highlights

Function

PFBA_STRR6 Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.