4myp

Structural highlights

Function

HBP2_LISMO Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable). At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable). Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1 (PubMed:25315777). May be involved in crossing the digestive barrier in infected animals (PubMed:15661014). Binds host hemin (Probable) (PubMed:21545655, PubMed:25315777). Binds host hemoglobin with affinity in the nanomolar range (PubMed:25315777).^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Newton SM, Klebba PE, Raynaud C, Shao Y, Jiang X, Dubail I, Archer C, Frehel C, Charbit A. The svpA-srtB locus of Listeria monocytogenes: fur-mediated iron regulation and effect on virulence. Mol Microbiol. 2005 Feb;55(3):927-40. doi: 10.1111/j.1365-2958.2004.04436.x. PMID:15661014 doi:http://dx.doi.org/10.1111/j.1365-2958.2004.04436.x
2. ↑ Xiao Q, Jiang X, Moore KJ, Shao Y, Pi H, Dubail I, Charbit A, Newton SM, Klebba PE. Sortase independent and dependent systems for acquisition of haem and haemoglobin in Listeria monocytogenes. Mol Microbiol. 2011 Jun;80(6):1581-97. doi: 10.1111/j.1365-2958.2011.07667.x. , Epub 2011 May 6. PMID:21545655 doi:http://dx.doi.org/10.1111/j.1365-2958.2011.07667.x
3. ↑ Malmirchegini GR, Sjodt M, Shnitkind S, Sawaya MR, Rosinski J, Newton SM, Klebba PE, Clubb RT. Novel Mechanism of Hemin Capture by Hbp2, the Hemoglobin-binding Hemophore from Listeria monocytogenes. J Biol Chem. 2014 Dec 12;289(50):34886-99. doi: 10.1074/jbc.M114.583013. Epub, 2014 Oct 14. PMID:25315777 doi:http://dx.doi.org/10.1074/jbc.M114.583013
4. ↑ Newton SM, Klebba PE, Raynaud C, Shao Y, Jiang X, Dubail I, Archer C, Frehel C, Charbit A. The svpA-srtB locus of Listeria monocytogenes: fur-mediated iron regulation and effect on virulence. Mol Microbiol. 2005 Feb;55(3):927-40. doi: 10.1111/j.1365-2958.2004.04436.x. PMID:15661014 doi:http://dx.doi.org/10.1111/j.1365-2958.2004.04436.x
5. ↑ Xiao Q, Jiang X, Moore KJ, Shao Y, Pi H, Dubail I, Charbit A, Newton SM, Klebba PE. Sortase independent and dependent systems for acquisition of haem and haemoglobin in Listeria monocytogenes. Mol Microbiol. 2011 Jun;80(6):1581-97. doi: 10.1111/j.1365-2958.2011.07667.x. , Epub 2011 May 6. PMID:21545655 doi:http://dx.doi.org/10.1111/j.1365-2958.2011.07667.x
6. ↑ Malmirchegini GR, Sjodt M, Shnitkind S, Sawaya MR, Rosinski J, Newton SM, Klebba PE, Clubb RT. Novel Mechanism of Hemin Capture by Hbp2, the Hemoglobin-binding Hemophore from Listeria monocytogenes. J Biol Chem. 2014 Dec 12;289(50):34886-99. doi: 10.1074/jbc.M114.583013. Epub, 2014 Oct 14. PMID:25315777 doi:http://dx.doi.org/10.1074/jbc.M114.583013