Structural highlights
Function
SEDS_STRE2 Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene selina-4(15),7(11)-diene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP leading to a (E,E)-germacradienyl cation (PubMed:23307484, PubMed:24890698). The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:23307484, PubMed:24890698).[1] [2]
References
- ↑ Rabe P, Dickschat JS. Rapid chemical characterization of bacterial terpene synthases. Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1810-2. doi: 10.1002/anie.201209103. , Epub 2013 Jan 10. PMID:23307484 doi:http://dx.doi.org/10.1002/anie.201209103
- ↑ Baer P, Rabe P, Fischer K, Citron CA, Klapschinski TA, Groll M, Dickschat JS. Induced-Fit Mechanism in Class I Terpene Cyclases. Angew Chem Int Ed Engl. 2014 May 30. doi: 10.1002/anie.201403648. PMID:24890698 doi:http://dx.doi.org/10.1002/anie.201403648
