4ppo

From Proteopedia

First Crystal Structure for an Oxaliplatin-Protein Complex

Structural highlights

4ppo is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.73Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSC_CHICK Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.^[1]

Publication Abstract from PubMed

The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.

The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme.,Messori L, Marzo T, Merlino A Chem Commun (Camb). 2014 Aug 7;50(61):8360-2. doi: 10.1039/c4cc02254h. PMID:24943911^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
↑ Messori L, Marzo T, Merlino A. The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme. Chem Commun (Camb). 2014 Aug 7;50(61):8360-2. doi: 10.1039/c4cc02254h. PMID:24943911 doi:http://dx.doi.org/10.1039/c4cc02254h