4quv

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Structure of an integral membrane delta(14)-sterol reductase

Structural highlights

4quv is a 2 chain structure with sequence from Methylotuvimicrobium alcaliphilum 20Z. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.743Å
Ligands:NDP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ERG_META2 Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Complements the deletion of the Delta(14)-sterol reductase gene ERG24 in yeast.[1]

References

  1. ↑ Li X, Roberti R, Blobel G. Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum. Nature. 2014 Oct 12. doi: 10.1038/nature13797. PMID:25307054 doi:http://dx.doi.org/10.1038/nature13797

Contents


PDB ID 4quv

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OCA

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