Structural highlights
Function
SUS_NITEU Catalyzes the reversible conversion of sucrose and a nucleotide disphosphate (NDP) into fructose and NDP-glucose; although the reaction is freely reversible in vitro, the physiological reaction seems to be sucrose cleavage. Unlike characterized plant enzymes prefers ADP as a cosubstrate, whereas plants prefer UDP (PubMed:25846332, PubMed:26013491). The KM for sucrose is 8-fold lower in the presence of ADP than UDP (PubMed:25846332). Its preference for ADP over UDP suggests it may directly link sucrose and glycogen metabolism (Probable).[1] [2]
References
- ↑ Diricks M, De Bruyn F, Van Daele P, Walmagh M, Desmet T. Identification of sucrose synthase in nonphotosynthetic bacteria and characterization of the recombinant enzymes. Appl Microbiol Biotechnol. 2015 Oct;99(20):8465-74. PMID:25846332 doi:10.1007/s00253-015-6548-7
- ↑ Wu R, Asencion Diez MD, Figueroa CM, Machtey M, Iglesias AA, Ballicora MA, Liu D. The Crystal Structure of Nitrosomonas europaea Sucrose Synthase Reveals Critical Conformational Changes and Insights into Sucrose Metabolism in Prokaryotes. J Bacteriol. 2015 Sep 1;197(17):2734-46. doi: 10.1128/JB.00110-15. Epub 2015 May , 26. PMID:26013491 doi:http://dx.doi.org/10.1128/JB.00110-15
