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Publication Abstract from PubMed

Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.

Structure of a left-handed DNA G-quadruplex.,Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT Proc Natl Acad Sci U S A. 2015 Feb 18. pii: 201418718. PMID:25695967^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.