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Publication Abstract from PubMed

The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.

Structure of the DNA Duplex d(ATTAAT)2 with Hoogsteen Hydrogen Bonds.,Acosta-Reyes FJ, Alechaga E, Subirana JA, Campos JL PLoS One. 2015 Mar 17;10(3):e0120241. doi: 10.1371/journal.pone.0120241., eCollection 2015. PMID:25781995^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.