4xal

Structural highlights

Function

VP22_HHV11 Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network. Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET.^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ van Leeuwen H, Okuwaki M, Hong R, Chakravarti D, Nagata K, O'Hare P. Herpes simplex virus type 1 tegument protein VP22 interacts with TAF-I proteins and inhibits nucleosome assembly but not regulation of histone acetylation by INHAT. J Gen Virol. 2003 Sep;84(Pt 9):2501-10. PMID:12917472
2. ↑ Yedowitz JC, Kotsakis A, Schlegel EF, Blaho JA. Nuclear localizations of the herpes simplex virus type 1 tegument proteins VP13/14, vhs, and VP16 precede VP22-dependent microtubule reorganization and VP22 nuclear import. J Virol. 2005 Apr;79(8):4730-43. PMID:15795259 doi:http://dx.doi.org/10.1128/JVI.79.8.4730-4743.2005
3. ↑ Mbong EF, Woodley L, Dunkerley E, Schrimpf JE, Morrison LA, Duffy C. Deletion of the herpes simplex virus 1 UL49 gene results in mRNA and protein translation defects that are complemented by secondary mutations in UL41. J Virol. 2012 Nov;86(22):12351-61. doi: 10.1128/JVI.01975-12. Epub 2012 Sep 5. PMID:22951838 doi:http://dx.doi.org/10.1128/JVI.01975-12
4. ↑ Maringer K, Stylianou J, Elliott G. A network of protein interactions around the herpes simplex virus tegument protein VP22. J Virol. 2012 Dec;86(23):12971-82. doi: 10.1128/JVI.01913-12. Epub 2012 Sep 19. PMID:22993164 doi:http://dx.doi.org/10.1128/JVI.01913-12
5. ↑ Starkey JL, Han J, Chadha P, Marsh JA, Wills JW. Elucidation of the block to herpes simplex virus egress in the absence of tegument protein UL16 reveals a novel interaction with VP22. J Virol. 2014 Jan;88(1):110-9. doi: 10.1128/JVI.02555-13. Epub 2013 Oct 16. PMID:24131716 doi:http://dx.doi.org/10.1128/JVI.02555-13
6. ↑ Elliott G, O'Hare P. Herpes simplex virus type 1 tegument protein VP22 induces the stabilization and hyperacetylation of microtubules. J Virol. 1998 Aug;72(8):6448-55. PMID:9658087