Structural highlights
Function
ACD11_CAEEL Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat.[1]
See Also
References
- ↑ Ma DK, Li Z, Lu AY, Sun F, Chen S, Rothe M, Menzel R, Sun F, Horvitz HR. Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell. 2015 May 21;161(5):1152-63. doi: 10.1016/j.cell.2015.04.026. Epub 2015 May , 14. PMID:25981666 doi:http://dx.doi.org/10.1016/j.cell.2015.04.026
