4yia

Structural highlights

Disease

THBG_HUMAN Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

Function

THBG_HUMAN Major thyroid hormone transport protein in serum.

See Also

• Serpin 3D structures