5b3g

Structural highlights

Function

SCR_ARATH Transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots. Essential for cell division but not differentiation of the ground tissue. Also required for normal shoot gravitropism. Regulates the radial organization of the shoot axial organs. Binds to the promoter of MGP, NUC, RLK and SCL3. Restricts SHR movment and sequesters it into the nucleus of the endodermis.^{[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]}

References

1. ↑ Wysocka-Diller JW, Helariutta Y, Fukaki H, Malamy JE, Benfey PN. Molecular analysis of SCARECROW function reveals a radial patterning mechanism common to root and shoot. Development. 2000 Feb;127(3):595-603. PMID:10631180
2. ↑ Sabatini S, Heidstra R, Wildwater M, Scheres B. SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem. Genes Dev. 2003 Feb 1;17(3):354-8. PMID:12569126 doi:http://dx.doi.org/10.1101/gad.252503
3. ↑ Sena G, Jung JW, Benfey PN. A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression. Development. 2004 Jun;131(12):2817-26. Epub 2004 May 13. PMID:15142972 doi:http://dx.doi.org/10.1242/dev.01144
4. ↑ Heidstra R, Welch D, Scheres B. Mosaic analyses using marked activation and deletion clones dissect Arabidopsis SCARECROW action in asymmetric cell division. Genes Dev. 2004 Aug 15;18(16):1964-9. PMID:15314023 doi:http://dx.doi.org/10.1101/gad.305504
5. ↑ Levesque MP, Vernoux T, Busch W, Cui H, Wang JY, Blilou I, Hassan H, Nakajima K, Matsumoto N, Lohmann JU, Scheres B, Benfey PN. Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis. PLoS Biol. 2006 May;4(5):e143. Epub 2006 May 2. PMID:16640459 doi:http://dx.doi.org/05-PLBI-RA-1464R2
6. ↑ Cui H, Levesque MP, Vernoux T, Jung JW, Paquette AJ, Gallagher KL, Wang JY, Blilou I, Scheres B, Benfey PN. An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. Science. 2007 Apr 20;316(5823):421-5. PMID:17446396 doi:http://dx.doi.org/316/5823/421
7. ↑ Cruz-Ramirez A, Diaz-Trivino S, Blilou I, Grieneisen VA, Sozzani R, Zamioudis C, Miskolczi P, Nieuwland J, Benjamins R, Dhonukshe P, Caballero-Perez J, Horvath B, Long Y, Mahonen AP, Zhang H, Xu J, Murray JA, Benfey PN, Bako L, Maree AF, Scheres B. A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division. Cell. 2012 Aug 31;150(5):1002-15. doi: 10.1016/j.cell.2012.07.017. Epub 2012 Aug , 23. PMID:22921914 doi:http://dx.doi.org/10.1016/j.cell.2012.07.017
8. ↑ Cruz-Ramirez A, Diaz-Trivino S, Wachsman G, Du Y, Arteaga-Vazquez M, Zhang H, Benjamins R, Blilou I, Neef AB, Chandler V, Scheres B. A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer. PLoS Biol. 2013 Nov;11(11):e1001724. doi: 10.1371/journal.pbio.1001724. Epub 2013, Nov 26. PMID:24302889 doi:http://dx.doi.org/10.1371/journal.pbio.1001724
9. ↑ Fukaki H, Fujisawa H, Tasaka M. SGR1, SGR2, SGR3: novel genetic loci involved in shoot gravitropism in Arabidopsis thaliana. Plant Physiol. 1996 Mar;110(3):945-55. PMID:8819871
10. ↑ Malamy JE, Benfey PN. Analysis of SCARECROW expression using a rapid system for assessing transgene expression in Arabidopsis roots. Plant J. 1997 Oct;12(4):957-63. PMID:9375406
11. ↑ Fukaki H, Wysocka-Diller J, Kato T, Fujisawa H, Benfey PN, Tasaka M. Genetic evidence that the endodermis is essential for shoot gravitropism in Arabidopsis thaliana. Plant J. 1998 May;14(4):425-30. PMID:9670559