Structural highlights
Publication Abstract from PubMed
RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base-pair interactions. Herein, we report the crystal-structure-guided design of highly stable RNA nanotriangles that self-assemble cooperatively from short oligonucleotides. The crystal structure of an 81 nucleotide nanotriangle determined at 2.6 A resolution reveals the so-far smallest circularly closed nanoobject made entirely of double-stranded RNA. The assembly of the nanotriangle architecture involved RNA corner motifs that were derived from ligand-responsive RNA switches, which offer the opportunity to control self-assembly and dissociation.
Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles.,Boerneke MA, Dibrov SM, Hermann T Angew Chem Int Ed Engl. 2016 Feb 23. doi: 10.1002/anie.201600233. PMID:26914842[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Boerneke MA, Dibrov SM, Hermann T. Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles. Angew Chem Int Ed Engl. 2016 Feb 23. doi: 10.1002/anie.201600233. PMID:26914842 doi:http://dx.doi.org/10.1002/anie.201600233