5d9h

Structural highlights

Function

STK39_MOUSE May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).^{[1] [2]}

See Also

• Serine/threonine protein kinase 3D structures

References

1. ↑ Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar;121(3):956-65. doi: 10.1172/JCI43475. Epub 2011 Feb 7. PMID:21317537 doi:http://dx.doi.org/10.1172/JCI43475
2. ↑ Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S. Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41. doi: 10.1053/j.gastro.2013.03.047. Epub, 2013 Mar 28. PMID:23542070 doi:http://dx.doi.org/10.1053/j.gastro.2013.03.047