Structural highlights
Function
Q1HRB8_AEDAE
Publication Abstract from PubMed
Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a single-domain, noncanonical Kazal-type serine proteinase inhibitor from A. aegypti that recognizes both digestive trypsin-like serine proteinases and the central protease in blood clotting, thrombin, albeit with an affinity that is three orders of magnitude lower. Here, the 1.4 A resolution crystal structure of AaTI is reported from extremely tightly packed crystals ( approximately 22% solvent content), revealing the structural determinants for the observed inhibitory profile of this molecule.
High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.,Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB. High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti. Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090 doi:http://dx.doi.org/10.1107/S2053230X17010007