5epo

Structural highlights

Function

HDHA_CLOSR 7alpha-hydroxysteroid dehydrogenase that catalyzes the NADP(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as cholate, chenodeoxycholate, glycochenodeoxycholate and taurochenodeoxycholate, to the corresponding 7-oxosteroids (PubMed:22198717, PubMed:24810359). Is also able to catalyze the reverse reduction reactions (PubMed:22198717). Together with 7beta-HSDH encoded in the adjacent gene, is likely involved in the epimerization of the hydroxy group at C-7 of primary bile acids through 7-keto bile acid intermediates (PubMed:22198717).^{[1] [2]}

See Also

• Hydroxysteroid dehydrogenase 3D structures

References

1. ↑ Ferrandi EE, Bertolesi GM, Polentini F, Negri A, Riva S, Monti D. In search of sustainable chemical processes: cloning, recombinant expression, and Appl Microbiol Biotechnol. 2012 Sep;95(5):1221-33. PMID:22198717 doi:10.1007/s00253-011-3798-x
2. ↑ Lou D, Wang B, Tan J, Zhu L. Carboxyl-terminal and Arg38 are essential for activity of the 7α-hydroxysteroid dehydrogenase from Clostridium absonum. Protein Pept Lett. 2014;21(9):894-900. PMID:24810359 doi:10.2174/0929866521666140507160050