5ij4

Structural highlights

Function

CUZ1_YEAST May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity.^{[1] [2]}

References

1. ↑ Sa-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, Hochstrasser M. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem. 2013 Nov 22;288(47):33682-96. doi: 10.1074/jbc.M113.521088. Epub, 2013 Oct 11. PMID:24121501 doi:http://dx.doi.org/10.1074/jbc.M113.521088
2. ↑ Hanna J, Waterman D, Isasa M, Elsasser S, Shi Y, Gygi S, Finley D. Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. J Biol Chem. 2014 Jan 17;289(3):1876-85. doi: 10.1074/jbc.M113.534032. Epub 2013 , Dec 2. PMID:24297164 doi:http://dx.doi.org/10.1074/jbc.M113.534032