5itv

Structural highlights

Function

BACC_BACSU Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the dehydrogenation of the C7-hydroxyl group in the 4S-tetrahydrotyrosine (4S-H4Tyr) to yield anticapsin (epoxycyclohexanonyl-Ala). It is not able to oxidize the 4R-H4Tyr diastereomer and the dihydrobacilysin dipeptide (L-Ala-4S-H4Tyr dipeptide).^{[1] [2]}

References

1. ↑ Steinborn G, Hajirezaei MR, Hofemeister J. bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains. Arch Microbiol. 2005 Feb;183(2):71-9. Epub 2004 Dec 18. PMID:15609023 doi:http://dx.doi.org/10.1007/s00203-004-0743-8
2. ↑ Parker JB, Walsh CT. Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin. Biochemistry. 2013 Feb 5;52(5):889-901. doi: 10.1021/bi3016229. Epub 2013 Jan 23. PMID:23317005 doi:http://dx.doi.org/10.1021/bi3016229