5j1j

Structural highlights

Function

FLEN_PSEAE ATPase that plays an important role in maintaining flagellar number in Pseudomonas aeruginosa (PubMed:10629180, PubMed:28065505). Exhibits anti-activator activity against FleQ, the global transcriptional regulator of flagellar genes (PubMed:22581773, PubMed:28065505).^{[1] [2] [3]}

References

1. ↑ Dasgupta N, Arora SK, Ramphal R. fleN, a gene that regulates flagellar number in Pseudomonas aeruginosa. J Bacteriol. 2000 Jan;182(2):357-64. PMID:10629180 doi:10.1128/JB.182.2.357-364.2000
2. ↑ Baraquet C, Murakami K, Parsek MR, Harwood CS. The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP. Nucleic Acids Res. 2012 Aug;40(15):7207-18. PMID:22581773 doi:10.1093/nar/gks384
3. ↑ Chanchal, Banerjee P, Jain D. ATP-Induced Structural Remodeling in the Antiactivator FleN Enables Formation of the Functional Dimeric Form. Structure. 2017 Feb 7;25(2):243-252. doi: 10.1016/j.str.2016.11.022. Epub 2017, Jan 5. PMID:28065505 doi:http://dx.doi.org/10.1016/j.str.2016.11.022