5klq

Structural highlights

Function

HOZ1A_PSESY Serine/threonine-protein acetyltransferase translocated into infected cells, which impairs host microtubule network and host immunity by mediating acetylation of target proteins (PubMed:20636323, PubMed:22319451, PubMed:24204266, PubMed:27525589). Blocks secretion in host cells by mediating acetylation of host tubulin, thereby impairing host microbubule network (PubMed:22319451). Impairs host cell immunity by mediating acetylation of host TIFY/JAZ transcription repressors (Arabidopsis thaliana TIFY10B/JAZ2, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5A/JAZ8, TIFY9/JAZ10 and TIFY3B/JAZ12), thereby activating host jasmonate signaling (PubMed:24204266, PubMed:27525589).^{[1] [2] [3] [4]}

References

1. ↑ Macho AP, Guevara CM, Tornero P, Ruiz-Albert J, Beuzón CR. The Pseudomonas syringae effector protein HopZ1a suppresses effector-triggered immunity. New Phytol. 2010 Sep;187(4):1018-1033. PMID:20636323 doi:10.1111/j.1469-8137.2010.03381.x
2. ↑ Lee AH, Hurley B, Felsensteiner C, Yea C, Ckurshumova W, Bartetzko V, Wang PW, Quach V, Lewis JD, Liu YC, Börnke F, Angers S, Wilde A, Guttman DS, Desveaux D. A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. PLoS Pathog. 2012 Feb;8(2):e1002523. PMID:22319451 doi:10.1371/journal.ppat.1002523
3. ↑ Jiang S, Yao J, Ma KW, Zhou H, Song J, He SY, Ma W. Bacterial effector activates jasmonate signaling by directly targeting JAZ transcriptional repressors. PLoS Pathog. 2013 Oct;9(10):e1003715. PMID:24204266 doi:10.1371/journal.ppat.1003715
4. ↑ Zhang ZM, Ma KW, Yuan S, Luo Y, Jiang S, Hawara E, Pan S, Ma W, Song J. Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family. Nat Struct Mol Biol. 2016 Aug 15. doi: 10.1038/nsmb.3279. PMID:27525589 doi:http://dx.doi.org/10.1038/nsmb.3279