Structural highlights
Function
MMGE_BACSU Involved in both the tricarboxylic acid (TCA) and methylcitric acid cycles (PubMed:28956599). Has both 2-methylcitrate dehydratase and citrate dehydratase activities. Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield 2-methyl-cis-aconitate, and the dehydration of citrate to yield cis-aconitate. Cannot form isocitrate. Uses either (2S,3R)- or (2R,3S)-2-methylcitrate (PubMed:28956599).[1]
References
- ↑ Reddick JJ, Sirkisoon S, Dahal RA, Hardesty G, Hage NE, Booth WT, Quattlebaum AL, Mills SN, Meadows VG, Adams SLH, Doyle JS, Kiel BE. First Biochemical Characterization of a Methylcitric Acid Cycle from Bacillus subtilis Strain 168. Biochemistry. 2017 Oct 24;56(42):5698-5711. PMID:28956599 doi:10.1021/acs.biochem.7b00778
