Structural highlights
Function
SRC8_MOUSE Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.[1] [2]
References
- ↑ Bourguignon LY, Gilad E, Peyrollier K, Brightman A, Swanson RA. Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. J Neurochem. 2007 May;101(4):1002-17. Epub 2007 Mar 30. PMID:17403031 doi:http://dx.doi.org/10.1111/j.1471-4159.2007.04485.x
- ↑ Chen YK, Hsueh YP. Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance. J Neurosci. 2012 Jan 18;32(3):1043-55. doi: 10.1523/JNEUROSCI.4405-11.2012. PMID:22262902 doi:http://dx.doi.org/10.1523/JNEUROSCI.4405-11.2012
