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5u9o

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Cocrystal structure of the intermembrane space region of the plastid division proteins PARC6 and PDV1

Structural highlights

5u9o is a 8 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.37Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDV1_ARATH Component of the plastid division machinery (PubMed:16998069). Required to mediate the dissociation of ARC5/DRP5B from plastid outer envelope membranes (OEMs) at the midplastid constriction site in the cytoplasm, thus triggering ARC5/DRP5B ring turnover at the chloroplast division site (PubMed:16998069, PubMed:32005784). Binding to phosphatidylinositol 4-phosphate (PI4P) modulates negatively chloroplast division (PubMed:25736058).^[1] ^[2] ^[3] CDP1_ARATH Component of the plastid division machinery required for PDV1 localization to constriction sites. Involved in chloroplast division site placement. Seems to inhibit FtsZ assembly, functioning as an antagonistic regulator of FtsZ dynamics against ARC6.^[4] ^[5]

References

↑ Miyagishima SY, Froehlich JE, Osteryoung KW. PDV1 and PDV2 mediate recruitment of the dynamin-related protein ARC5 to the plastid division site. Plant Cell. 2006 Oct;18(10):2517-30. Epub 2006 Sep 22. PMID:16998069 doi:http://dx.doi.org/10.1105/tpc.106.045484
↑ Okazaki K, Miyagishima SY, Wada H. Phosphatidylinositol 4-phosphate negatively regulates chloroplast division in Arabidopsis. Plant Cell. 2015 Mar;27(3):663-74. PMID:25736058 doi:10.1105/tpc.115.136234
↑ Sun B, Zhang QY, Yuan H, Gao W, Han B, Zhang M. PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring. Plant Physiol. 2020 Apr;182(4):1966-1978. PMID:32005784 doi:10.1104/pp.19.01490
↑ Glynn JM, Yang Y, Vitha S, Schmitz AJ, Hemmes M, Miyagishima SY, Osteryoung KW. PARC6, a novel chloroplast division factor, influences FtsZ assembly and is required for recruitment of PDV1 during chloroplast division in Arabidopsis. Plant J. 2009 Sep;59(5):700-11. doi: 10.1111/j.1365-313X.2009.03905.x. Epub 2009 , May 2. PMID:19453460 doi:http://dx.doi.org/10.1111/j.1365-313X.2009.03905.x
↑ Zhang M, Hu Y, Jia J, Li D, Zhang R, Gao H, He Y. CDP1, a novel component of chloroplast division site positioning system in Arabidopsis. Cell Res. 2009 Jul;19(7):877-86. doi: 10.1038/cr.2009.78. PMID:19564892 doi:http://dx.doi.org/10.1038/cr.2009.78