| Structural highlights
Function
DPY21_CAEEL Required for X chromosome dosage compensation by reducing X-linked gene transcription in hermaphrodites throughout development (PubMed:14660541, PubMed:23028348, PubMed:3779843, PubMed:3478715, PubMed:26641248, PubMed:22393255). Might be involved in the regulation of histone H4 post-translational modifications on the X chromosome leading to transcriptional repression of X-linked genes (PubMed:22393255, PubMed:23028348, PubMed:26641248). Involved in the regulation of growth, fecundity and body fat metabolism downstream of the TOR complex 2 and the protein kinase sgk-1 pathway (PubMed:23884442). Also involved in male tail development (PubMed:6537930).[1] [2] [3] [4] [5] [6] [7] [8]
References
- ↑ Yonker SA, Meyer BJ. Recruitment of C. elegans dosage compensation proteins for gene-specific versus chromosome-wide repression. Development. 2003 Dec;130(26):6519-32. PMID:14660541 doi:http://dx.doi.org/10.1242/dev.00886
- ↑ Wells MB, Snyder MJ, Custer LM, Csankovszki G. Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes. Mol Cell Biol. 2012 May;32(9):1710-9. doi: 10.1128/MCB.06546-11. Epub 2012 Mar 5. PMID:22393255 doi:http://dx.doi.org/10.1128/MCB.06546-11
- ↑ Vielle A, Lang J, Dong Y, Ercan S, Kotwaliwale C, Rechtsteiner A, Appert A, Chen QB, Dose A, Egelhofer T, Kimura H, Stempor P, Dernburg A, Lieb JD, Strome S, Ahringer J. H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation. PLoS Genet. 2012 Sep;8(9):e1002933. doi: 10.1371/journal.pgen.1002933. Epub 2012 , Sep 13. PMID:23028348 doi:http://dx.doi.org/10.1371/journal.pgen.1002933
- ↑ Webster CM, Wu L, Douglas D, Soukas AA. A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2. Development. 2013 Sep;140(17):3601-12. doi: 10.1242/dev.094292. Epub 2013 Jul 24. PMID:23884442 doi:http://dx.doi.org/10.1242/dev.094292
- ↑ Kramer M, Kranz AL, Su A, Winterkorn LH, Albritton SE, Ercan S. Developmental Dynamics of X-Chromosome Dosage Compensation by the DCC and H4K20me1 in C. elegans. PLoS Genet. 2015 Dec 7;11(12):e1005698. doi: 10.1371/journal.pgen.1005698., eCollection 2015 Dec. PMID:26641248 doi:http://dx.doi.org/10.1371/journal.pgen.1005698
- ↑ Donahue LM, Quarantillo BA, Wood WB. Molecular analysis of X chromosome dosage compensation in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7600-4. PMID:3478715
- ↑ Meyer BJ, Casson LP. Caenorhabditis elegans compensates for the difference in X chromosome dosage between the sexes by regulating transcript levels. Cell. 1986 Dec 26;47(6):871-81. PMID:3779843
- ↑ Meneely PM, Wood WB. An autosomal gene that affects X chromosome expression and sex determination in Caenorhabditis elegans. Genetics. 1984 Jan;106(1):29-44. PMID:6537930
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