Structural highlights
Function
FOM1_STRWE Bifunctional enzyme that catalyzes two steps during fosfomycin biosynthesis (PubMed:28727444). It catalyzes the conversion of phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy), the first step of the pathway. It also catalyzes the cytidylylation of the 2-hydroxyethylphosphonate (HEP) intermediate to produce cytidylyl-2-hydroxyethylphosphonate (HEP-CMP), the fourth step of the pathway (PubMed:28727444).[1]
References
- ↑ Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T. Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme. ACS Chem Biol. 2017 Aug 18;12(8):2209-2215. doi: 10.1021/acschembio.7b00419. Epub, 2017 Jul 20. PMID:28727444 doi:http://dx.doi.org/10.1021/acschembio.7b00419
