5xoh

Structural highlights

Function

BMT_KITPR O-methyltransferase involved in the biosynthesis of furocoumarins natural products such as bergapten, a photosensitizer used for medical purpose such as treating psoriasis and vitiligo or facilitating resistance to microbial infection and other stresses (PubMed:30934718, PubMed:27252733, PubMed:31666994). Catalyzes specifically the methylation of bergaptol (PubMed:30934718, PubMed:27252733, PubMed:31666994). Not active on xanthotol, isoscopoletin, scopoletin and esculetin (PubMed:30934718, PubMed:27252733).^{[1] [2] [3]}

References

1. ↑ Zhao Y, Wang N, Zeng Z, Xu S, Huang C, Wang W, Liu T, Luo J, Kong L. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci. 2016 May 25;7:722. PMID:27252733 doi:10.3389/fpls.2016.00722
2. ↑ Zhao Y, Wang N, Sui Z, Huang C, Zeng Z, Kong L. The Molecular and Structural Basis of O-methylation Reaction in Coumarin Biosynthesis in Peucedanum praeruptorum Dunn. Int J Mol Sci. 2019 Mar 27;20(7). pii: ijms20071533. doi: 10.3390/ijms20071533. PMID:30934718 doi:http://dx.doi.org/10.3390/ijms20071533
3. ↑ Zhao Y, Wang N, Wu H, Zhou Y, Huang C, Luo J, Zeng Z, Kong L. Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment. J Adv Res. 2019 Oct 10;21:57-64. PMID:31666994 doi:10.1016/j.jare.2019.10.003