Structural highlights
Function
FERM2_MOUSE Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.[1] [2] [3]
References
- ↑ Dowling JJ, Gibbs E, Russell M, Goldman D, Minarcik J, Golden JA, Feldman EL. Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ Res. 2008 Feb 29;102(4):423-31. doi: 10.1161/CIRCRESAHA.107.161489. Epub, 2008 Jan 3. PMID:18174465 doi:http://dx.doi.org/10.1161/CIRCRESAHA.107.161489
- ↑ Montanez E, Ussar S, Schifferer M, Bosl M, Zent R, Moser M, Fassler R. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008 May 15;22(10):1325-30. doi: 10.1101/gad.469408. PMID:18483218 doi:http://dx.doi.org/10.1101/gad.469408
- ↑ Pluskota E, Dowling JJ, Gordon N, Golden JA, Szpak D, West XZ, Nestor C, Ma YQ, Bialkowska K, Byzova T, Plow EF. The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish. Blood. 2011 May 5;117(18):4978-87. doi: 10.1182/blood-2010-11-321182. Epub 2011, Mar 4. PMID:21378273 doi:http://dx.doi.org/10.1182/blood-2010-11-321182
