5yh5

Structural highlights

Function

CNTA_STAA8 Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Binds the metal via the metallophore StP, and transfers the StP-metal complex to the membrane-bound permease (PubMed:23279021, PubMed:29581261). Binds one molecule of StP/metal. Binds StP/Co(2+) and StP/Ni(2+) tighter than StP/Zn(2+) (PubMed:29581261). Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro (PubMed:23279021).^{[1] [2]}

See Also

• ABC transporter 3D structures

References

1. ↑ Remy L, Carrière M, Derré-Bobillot A, Martini C, Sanguinetti M, Borezée-Durant E. The Staphylococcus aureus Opp1 ABC transporter imports nickel and cobalt in zinc-depleted conditions and contributes to virulence. Mol Microbiol. 2013 Feb;87(4):730-43. PMID:23279021 doi:10.1111/mmi.12126
2. ↑ Song L, Zhang Y, Chen W, Gu T, Zhang SY, Ji Q. Mechanistic insights into staphylopine-mediated metal acquisition. Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 1718382115. doi:, 10.1073/pnas.1718382115. PMID:29581261 doi:http://dx.doi.org/10.1073/pnas.1718382115