Structural highlights
Function
COATR_MYCTU Probably involved in fatty acid metabolism. Binds to fatty acyl-CoAs of varying carbon chain lengths, with the highest binding affinity for palmitoyl-CoA (C16:0). In vitro, alters the cell wall lipid profile and protects mycobacteria from acidic, oxidative and antibiotic stress. May play a significant role in host-pathogen interaction.[1]
References
- ↑ Karade SS, Pandey S, Ansari A, Das S, Tripathi S, Arora A, Chopra S, Pratap JV, Dasgupta A. Rv3272 encodes a novel Family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress. Biochim Biophys Acta Proteins Proteom. 2018 Oct 17. pii: S1570-9639(18)30180-8., doi: 10.1016/j.bbapap.2018.10.011. PMID:30342240 doi:http://dx.doi.org/10.1016/j.bbapap.2018.10.011
